Synthetic cephalosporins the synthesis and antibacterial activities of 7-(2-(2-(amino-1,3,4-thiadiazol-5-yl)acetamido)cephalosporins.
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چکیده
منابع مشابه
Synthesis and antibacterial screening of some 2-(p-substituted benzylidene)-3- (5-ethyl-1,3,4-thiadiazol-2-yl)thiazolidin-4-ones
A series of 2-(p-substituted benzylidene)-3-(5-ethyl-1, 3, 4-thiadiazol-2-yl) thiazolidin-4-ones were synthesized by the reaction of Schiff’s bases of N-(p-substituted benzylidene)-5-ethyl-1, 3, 4-thiadiazole-2-amines with thioglycolic acid in 1, 4-dioxane as solvent and studied for their in vitro antibacterial activity. Reaction of thiosemicarbazide with propanoic acid in presence of concentra...
متن کاملSynthesis and antibacterial activities of novel C(7)-catechol-substituted cephalosporins (I).
Cephalosporins have been widely used for treating diseases caused by pathogenic bacteria in human and animals. Through the tonB dependent iron transport mechanism,1>2) the use of catechol substituted /Mactams was knownto increase the drug's penetration into the bacterial cell walls. Thus, several catechol-substituted /Mactams have been synthesized and showed good antipseudomonal activities.3 ~ ...
متن کاملCephalosporins. VII. Synthesis and antibacterial activity of new cephalosporins bearing a 2-imino-3-hydroxythiazoline (2-aminothiazole N-oxide) in the C-7 acylamino side chain.
Introduction of a hydroxyl group into the thiazole ring nitrogen of cephalosporins belonging to the cefotiam and cefotaxime families gave rise to products, better described by the tautomeric N-oxide form, which proved particularly active against Gram-negative bacteria. Cephems bearing a (Z)-alkoxyimino functionality are of special interest for broadness of spectrum; among them, 7 beta-[(Z)-2-(2...
متن کاملSynthesis and in vitro Antibacterial Activity of Some Novel 2-Amino-4, 6-D Derivatives
Heterocyclic systems are one of the most important classes of organic compounds present in nature or synthesized in laboratory. These compounds posses an array of biological activities and are employed in the treatment of commonly occurring diseases. Keeping this in view, some new 2-amino-4,6-diarylpyrimidine from chalcones were synthesized. Eight novel 2-amino-4,6-diarylpyrimidine derivatives ...
متن کاملN-(5-Mercapto-1,3,4-Thiadiazol-2-yl)-2-Phenylacetamide Derivatives: Synthesis and In-vitro Cytotoxicity Evaluation as Potential Anticancer Agents
A new series of N-(5-Mercapto-1,3,4-thiadiazol-2-yl)-2-phenylacetamide derivatives (3a-3j) were synthesized via an amidation reaction using EDC and HOBt in acetonitrile solvent at room temperature condition. Chemical structures were characterized by 1H NMR, IR and MS spectroscopic methods and related melting points were also determined. The anticancer activity was evaluated using MTT procedure ...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1983
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.36.1205